ABSTRACT
The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin [median = 1] and the control group [median = 2; p < 0.05]. The grade of inflammation of the curcumin [median = 1] and the sham [median = 0] group was significantly lower than that of the control group [median = 3; p < 0.01 and p < 0.001, respectively]. Hydroxyproline levels were significantly lower in the sham [48.3 +/- 11.8 microg/mg] and the curcumin [63.8 +/- 13.9 microg/mg] group compared to the control group [85.7 +/- 22.1 microg/mg; p < 0.05]. These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation